Attack Presentation

FIRAZYR is indicated for the treatment of acute attacks of hereditary angioedema (HAE) in adults 18 years of age and older.

Symptoms of HAE

Attacks typically cause swelling of the skin/subcutaneous tissues, gastrointestinal tract, and upper airways, some of which may be painful and functionally disabling.1-3

Skin/subcutaneous tissue

Photo of a woman without and during a hereditary angioedema (HAE) attack causing swelling to the face.

Typically affects the face, extremities, and genitals and can be disabling and disfiguring at the time of the attack3

Photos courtesy of US Hereditary Angioedema Association. www.haeimages.com

Gastrointestinal tract

Photo of a hereditary angioedema patient without and during an HAE attack causing abdominal (stomach) swelling.

May present with mild to severe abdominal pain accompanied by vomiting and/or diarrhea4

Photos courtesy of US Hereditary Angioedema Association. www.haeimages.com

Upper airway, including the larynx

Photo of a hereditary angioedema patient without and during an HAE swelling attack in the throat.

Laryngeal attacks can cause death by asphyxiation; 50% of patients experience at least 1 laryngeal episode during their lifetime2,4,5,a

aIn a survey of 209 patients.5

Photos courtesy of Bas M, et al. Allergy. 2006;61(12):1490-1492.6

Many patients may experience prodromal symptoms before an HAE attack, including2,7:

  • A tingling sensation
  • Erythema marginatum, a mild, nonpruritic rash
  • Fatigue and malaise
  • Nausea
  • Muscle aches
  • Neurologic symptoms