How FIRAZYR works

FIRAZYR is used to treat acute attacks of hereditary angioedema (HAE) in adults 18 years of age and older. FIRAZYR is the first FDA-approved injection you give yourself under the skin (subcutaneously) to treat acute attacks of HAE—both in and out of the home—after you have been trained by a healthcare professional.

How does FIRAZYR work?

Most people with HAE don’t have enough of a protein called C1 esterase inhibitor, or this protein does not work as it should, which contributes to a cascade of events in the body. This cascade causes another protein called plasma kallikrein to trigger the release of a third protein called bradykinin. Having too much bradykinin causes the blood vessels to release fluid, resulting in the localized swelling and pain of an HAE attack.

Comparison of untreated person with HAE after treatment with FIRAZYR® (icatibant injection). FIRAZYR® (icatibant injection) blocks bradykinin from binding to B2 receptors which treats the symptoms of an acute HAE attack.

Reach for FIRAZYR First

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