Attack Presentation

FIRAZYR is indicated for the treatment of acute attacks of hereditary angioedema (HAE) in adults 18 years of age and older.
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HAE attacks

HAE is characterized by unpredictable, recurrent, and sometimes painful edema attacks that can affect extremities, genitals, the face, gastrointestinal (GI) tract and upper airways. They are generally categorized according to anatomical site as cutaneous, abdominal or laryngeal. The symptoms of each attack type are listed below.1,2

Attacks: Cutaneous

Photo of a woman before and during a facial hereditary angioedema (HAE) attack.
  • Typically affects face, extremities and genitals2
  • Can be disabling and disfiguring at the time of the attack2
  • Facial swelling can extend to laryngeal edema3*

*According to a survey of 158 patients

Photos courtesy of US Hereditary Angioedema Association. www.haeimages.com

Attacks: Abdominal

Photo of a woman before and during an abdominal hereditary angioedema (HAE) attack.
  • May present with symptoms varying from mild discomfort to severe abdominal pain accompanied by vomiting and/or diarrhea2
  • Diagnostic uncertainty contributes to unnecessary surgeries2

Photos courtesy of US Hereditary Angioedema Association. www.haeimages.com

Attacks: Laryngeal

Photo of a woman before and during a laryngeal hereditary angioedema (HAE) attack.
  • Approximately 50% of patients may suffer a laryngeal attack in their lifetime3*
  • These can cause death by asphyxiation, even with no history of laryngeal involvement4

*In a survey of 209 patients

Photos courtesy of Bas M, et al. Allergy. 2006;61(12):1490-1492.

The site at which the HAE attack occurs varies among patients. Some patients experience simultaneous or closely spaced abdominal and cutaneous involvement.2

In a retrospective analysis of 209 patients presenting with symptoms of HAE, 96% of patients experienced cutaneous edema, including facial swelling; 93% had recurrent abdominal attacks; approximately 52% had laryngeal attacks (the total number of laryngeal attacks represented 0.9% of all attacks).3